Nanoparticle Targeting with Antibodies in the Central Nervous System

Treatments for disease in the central nervous system (CNS) are limited because of difficulties agent penetration through blood-brain barrier, achieving optimal dosing, and mitigating off-target effects. The prospect precision medicine CNS treatment suggests an opportunity therapeutic nanotechnology, which offers tunability adaptability to address specific diseases as well targetability when combined with antibodies (Abs). Here, we review strategies attach Abs nanoparticles (NPs), including conventional approaches chemisorption physisorption attempts combine irreversible Ab immobilization controlled orientation. We also summarize trends that have been observed studies systemically delivered Ab–NP conjugates animals. Finally, discuss future outlook Ab–NPs deliver therapeutics into CNS.